Human Hypertrophic Cardiomyopathy Abnormalities, Irrespective of Cardiac Hypertrophy, in a Transgenic Rabbit Model of Tissue Doppler Imaging Consistently Detects Myocardial Contraction and Relaxation
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Sherif F. Nagueh, Helen A. Kopelen, Do-Sun Lim, William A. Zoghbi, Miguel A. Quiñones, Human Hypertrophic Cardiomyopathy Abnormalities, Irrespective of Cardiac Hypertrophy, in a Transgenic Rabbit Model of Tissue Doppler Imaging Consistently Detects Myocardial Contraction and Relaxation Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.102.12.1346 2000;102:1346-1350 Circulation. http://circ.ahajournals.org/content/102/12/1346 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy.
BACKGROUND Hypertrophic cardiomyopathy (HCM) is diagnosed clinically by the presence of left ventricular hypertrophy (LVH). However, LVH is absent in a significant number of genotype-positive patients. Because myocyte dysfunction and disarray are the primary abnormalities in HCM, we reasoned that tissue Doppler imaging could identify contraction and relaxation abnormalities, irrespective of hyp...
متن کاملTissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy.
BACKGROUND Left ventricular hypertrophy (LVH), the clinical hallmark of familial hypertrophic cardiomyopathy (FHCM), is absent in a significant number of subjects with causal mutations. In transgenic rabbits that fully recapitulate the FHCM phenotype, reduced myocardial tissue Doppler (TD) velocities accurately identified the mutant rabbits, even in the absence of LVH. We tested whether humans ...
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Background: The prevalence of gestational diabetes mellitus is rising. Myocardial hypertrophy is the most common cardiac disorder in the infants of diabetic mothers, which hypothetically can cause fatal arrhythmias. This study investigated prolonged QT in the newborns of diabetic mothers in Afzalipour Hospital in Kerman City, in 2015. Methods: This case-contro...
متن کاملTransgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy.
BACKGROUND Transgenic and gene-targeted models have focused on the mouse. Fundamental differences between the mouse and human exist in Ca2+ handling during contraction/relaxation and in alterations in Ca2+ flux during heart failure, with the rabbit more accurately reflecting the human system. METHODS AND RESULTS Cardiac troponin I (cTnI) mutations can cause familial hypertrophic cardiomyopath...
متن کامل[Usefulness of pulsed Doppler tissue imaging in the early detection of diastolic myocardial abnormalities in first-degree relatives of patients with familial hypertrophic cardiomyopathy].
INTRODUCTION AND OBJECTIVES Doppler tissue imaging (DTI) enables regional myocardial function to be assessed irrespective of preload. Our aim was to determine the usefulness of DTI in healthy relatives of patients with familial hypertrophic cardiomyopathy. PATIENTS AND METHOD We studied 47 first-degree relatives of patients with familial hypertrophic cardiomyopathy (group GI) and 47 normal su...
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تاریخ انتشار 2000